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ApoE2 occurs in roughly 510% of people and is generally associated with a lower risk of coronary artery diseasealthough it may increase the risk of atherosclerosis in certain cases

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This results in the accumulation of reactive oxygen species (ROS) and mitochondrial dysfunction

2025;12:e269-e281

2.15 C57BL/6 mice insights into Alzheimers disease research C57BL/6 mice are the most extensively used models in AD research, owing to their exceptional genetic stability, robust breeding capabilities, and adaptability to laboratory conditions