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As a result, the physiological regulation of Keap1-Nrf2 is lost, and free NAPQI reacts with protein sulfhydryl groups to form APAP adducts (Figure 1)

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After infecting the alveolar macrophage, Mtb then gains access to the lung interstitium, where granuloma formation occurs (115)

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& Kumanogoh, A

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11,12 HIF proteins have different alpha and beta subunits, which form a structure called a heterodimers

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