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Hydrogen sulfide (H 2 S) is recognized as the third gasotransmitter, alongside nitric oxide (NO) and carbon monoxide (CO)

10.1016/j.carbpol.2017.07.014 192 LiuJ.QianZ.ShiQ.YangS.WangQ.LiuB.et al (2017c)

For example, damaged NMD reduces the expression of the tumor suppressor CYLD, a deubiquitinase that negatively regulates the NF-B pathway [142, 143]

Once IRS is phosphorylated, downstream signaling pathways are activated, including the phosphoinositide 3-kinase (PI3K) cascade and extracellular signal-regulated kinase (ERK)