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Peroxiredoxin I participates in the protection of reactive oxygen species-mediated cellular senescence

Indeed, the LKB1/AMPK signaling pathway has tumor suppressor activity since it serves as a metabolic checkpoint arresting cell growth in conditions of nutrient deprivation or low intracellular ATP levels[126]

Leuk Lymphoma (2016) 57:243740

Isoform specificity One way in which therapeutics against glutamine metabolism could be made more specific is by developing drugs against the particular isoforms of metabolic enzymes that are required in each tumour type, especially isoforms that are not commonly expressed in normal tissues