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Description

The human and murine colorectal carcinoma cell lines HCT116 (Expasy accession: CVCL_0291) and CT26 (CVCL_7254), respectively, were obtained from the American Type Culture Collection (ATCC) (Rockville, MD, USA), and the human ovarian cancer cell line A2780 (CVCL_0134, product number 93112519) together with its cisplatin-resistant subline A2780/Cis (93112517) from Sigma Aldrich

Overexpression of Cyclin D1 and Cyclin B1, key rate-limiting regulators for G1/S and G2/M phase transitions, respectively, disrupts cellular proliferation control, impairs differentiation and facilitates oncogenic progression (30)