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This model using hCMEC/D3 favored ECD, by decreasing cell proliferation, increasing caspase 3/7 levels, inducing apoptosis, increasing oxidative phosphorylation, inducing mitochondrial dysfunction, and promoting higher cell migration [115]

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The combination of isatuximab-Kd was further investigated in the Phase III IKEMA trial, a randomized, open-label study conducted across 16 countries in North America, South America, Europe, and the AsiaPacific region [54, 64]

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