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Consistent with the idea that this axis is required for resistance to DNA-damaging agents, knockdown of either CrAT or CrOT, which decreased histone acetylation (Extended Data Fig

The closest human data is from CB4211, an analog that completed Phase 1a/1b safety testing

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NSAIDs should be reserved for symptoms and inflammatory conditions for which lower risk analgesics (e.g., acetaminophen) have either failed or are not clinically indicated