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A thorough evaluation by an endocrinologist is required before enrollment

* Based on the trial product estimand: estimated efficacy in an idealized scenario in which all patients stayed on treatment and took no other weight loss therapies ** Based on the treatment policy estimand: estimated efficacy regardless of whether patients stayed on treatment or took other weight loss therapies About CagriSema CagriSema is being investigated by Novo Nordisk as a once-weekly subcutaneous injectable treatment for adults with overweight or obesity (REDEFINE program) and as a treatment for adults with type 2 diabetes (REIMAGINE program)

Statistical examinations were conducted using two-way analysis of variance (ANOVA) for animal body weight (in gram), and one-way ANOVA followed by Tukeys multiple comparison test for the total exploring time, the DI values, biochemical analysis, phytochemical assessments, the counts of BrdU/NeuN and DCX