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Cu deficiency reduces the expression of adhesion molecules such as ICAM-1 and VCAM-1, which mediate the adhesion of leukocytes to activated endothelial cells

Selenium is a trace mineral that is essential for the function of glutathione peroxidase, an enzyme that protects your cells

Annals of the New York Academy of Sciences, 959, 360367

Long-term safety : There isnt much data beyond 6 months, but given its historical use, its believed to be safe long-term