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Autophagy, i.e., the internal mechanism for recycling, biosynthesis and degradation of constituents and organelles via lysosomes, is probably the most essential universal process for the survival of all kinds of cells (He and Klionsky, 2009)

Oxidative stress also causes small-airway fibrosis

The monoamine hypothesis of depression has been the main pathophysiology and drug therapy target of depression over the past few decades, but the current monoamine theory has serious limitations (105)