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Therefore, CGAS/STING may contribute to ferroptosis in depression, given its involvement in multiple CNS disorders, its capacity to induce ferroptosis in various central and peripheral tissues, and importantly, the observation that its inhibition can effectively alleviate depressive-like behaviors

The effects of R001 include the early induction of oxidative stress events in TNBC cells, leading to DNA damage, altered cell cycle profile, and tumor cell death, and tumor growth inhibition in vivo

Garcia P, Schmiedlin-Ren P, Mathias JS, Tang H, Christman GM, Zimmermann EM

Additionally, studies evaluating the role of ATs in human diseases rarely define which specific ROS are involved, their sources, how they reach their molecular targets, and which targets are affected, and why