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Once transported into cells, DHA undergoes a GSH-dependent, two-electron reduction to VitC, catalyzed by redox enzymes including glutaredoxin, omega-class glutathione transferases and protein-disulfide isomerase 10,11,12,13

Yes, but chances are diet alone wont suffice, however dietary supplementation can have benefits

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The study highlights that PEGylated PLGA nanoparticles, could offer a promising alternative for the safe delivery of tolcapone, maintaining its therapeutic effects while significantly reducing associated hepatotoxicity 129

JAK-STAT Pathway: Crucial for cytokine signaling, the JAK-STAT pathway significantly influences CS through cytokines like IL-6, TNF, and IFN-, making it an important therapeutic target in managing severe inflammatory responses