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Treatment with MTX (20 mg/kg) caused a 36% reduction in serum albumin compared to the control

Fox ME, Chandra R, Menken MS, Larkin EJ, Nam H, Engeln M, et al

Jennifer M Poti, Michelle A Mendez, Shu Wen Ng, Barry M Popkin

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In a study by Moro et al (73) on patient-derived xenografts (PDXs), metformin (100 mg/kg/day) partially inhibited the tumor growth of PDXs with wild-type LKB1 (maximum inhibition rate, 50.514.8%), but had no significant inhibitory effect on LKB1-mutant PDXs, and with increasing doses of metformin, p-AMPK expression was increased and Ki67 expression was decreased, indicating that LKB1-deficient tumors have an impaired ability to adapt to metabolic stress induced by metformin treatment