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Treatment of HCC cells with ADI-PEG20 downregulates the key enzymes of pyrimidine synthesis in the TCA cycle, carbamoyl phosphate synthetase 2, thymine synthase (TS), aspartate transcarbamylase and dihydrooratase (CAD) and malate dehydrogenase 1 (MDH-1) activities, making tumor cells more susceptible to 5-fluorouracil (5-FU)

GR: Received lecture fees, consultancy fees from Takeda, Janssen, AbbVie, Celltrion, Pfizer, Bristol Myers Squibb, Ferring, Eli Lilly, Sanprobi, Pharmabest, Alfasigma, Bioton

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This multi-staged, collaborative approach between developers, regulators, and academic partners is critical to building the evidentiary basis required for OoCs to be accepted as trustworthy preclinical or diagnostic tools