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Participants with renal impairment were excluded if they had previously undergone renal transplantation or had unstable renal function or acute exacerbation of renal disease within 14 days of baseline, as indicated by recent history or worsening of clinical or laboratory signs

These data support that cellular senescence can be a new target for AKI management and restoring its balance could have prospective benefits

Human tissue was obtained from the National Institutes of Health NeuroBioBank at the University of Miami Brain Endowment Bank and University of Pittsburgh Brain Tissue Donation Program