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In AD, several miRNAs are downregulated, leading to increased ROS production and oxidative damage to neurons, which in turn, lead to cell death

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In the brain of patients with mild cognitive impairment (MCI) and those with AD, the level of markers of oxidative damage to DNA, proteins, and lipids is increased, while the expression and activities of glutathione and antioxidant enzymes are reduced (reviewed in 102)