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Fatigue is a documented side effect of tirzepatide, particularly during the first 4 to 6 weeks of titration

In models of hind limb ischemia, it accelerated blood flow recovery and increased vessel density, highlighting its pro-angiogenic properties

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however, vascular complications were not improved, most likely due to the excessive SOD-catalyzed formation of hydrogen peroxide, which causes endothelial damage (Rochette et al

These groups received intravenous administration of fluorescent drugs, each at a dosage of 2 mg/kg body weight