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Bhattacharya SK, Satyan KS, Chakrabarti A (1997) Anxiogenic action of caffeine: an experimental study in rats

For data, see Table 3

In this study, participants either were given Module 1 or 2

Dose escalation typically follows the classic 3 + 3 design, starting from extremely low doses and gradually increasing to higher doses [130]

Alternatively, use made be made of the local lymph node assay, the results of which can be interpreted to yield an objective estimate of relative sensitizing potency (Kimber & Basketter, 1997)