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Innate and adaptive immune responses against coronavirus

In contrast, zVAD had a minimal effect on ibrutinib-induced cell death, suggesting that apoptosis plays only a minor role, whereas ferroptosis contributes more prominently to the cytotoxic effects of ibrutinib (Fig

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Mechanistically, the inflammation mediated by the Caspase-1/NLRP3, TLR4/NLRP3, MAPK/NF-B/NLRP3, and Nrf2/HO-1/NLRP3 pathways have been implicated in the pathogenesis and progression of AP (Papantoniou et al., 2024), highlighting their potential as therapeutic targets

By expanding our understanding of cccDNA formation, a key factor in HBVs resistance to standard treatments, Wei and Ploss are paving the way for the development of new, more effective therapies