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Exploiting the computational algorithm, convergent motifs for binding sites (COMBS) for designing a small-molecule binding protein, Dang, DeGrado, and coworkers prepared a highly specific de novo protein, Apixaban binding helical bundle ( ABLE ) and PARP inhibitor binder ( PiB ) proteins for the rapid clearance of the achiral antithrombotic drug apixaban and the anticancer drug rucaparib , respectively (Fig

The two branches of the PPP can function together in three different modes based on cellular requirements: pentose insufficiency, pentose overflow and pentose cycling (Fig

The lack of convergence in efforts to identify etiological agents suggests that generic host responses to multiple microbial triggers may be important in its pathogenesis, and that ME/CFS and other post-infectious syndromes may represent a broader category 4,5

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The concentration of iron in glial cells is higher than that in neurons, and the maintenance of iron homeostasis in the central nervous system mainly depends on astrocytes (Dusek et al