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Here, we will (a) examine approaches to elucidate the GCN2methionineROS circuit to determine what forms of therapeutic modulation for T cell immunotherapies may be beneficial in a given context, and (b) explore different nodes within the GCN2-methionine-ROS circuit where intervention may be advantageous

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Extracellular Signaling Mediated by -Glutamyl Peptides Produced by GGT Another question that also remains unanswered is that of why the -glutamyl group in glutathione is metabolized differently by extracellular GGT and intracellular CHAC

Genome Res 10:703713