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In chronic cases of hip tendon pain, the studies have shown tendon degeneration due to repetitive microtrauma

Orphanet J Rare Dis 18:389

However, the preceding sections of this paper establish that GSH is not merely a passive antioxidant, but an immune regulator and modulator with actions dependent upon the pathophysiologic context (Ghezzi, 2011) GSH acts to regulate the thresholds necessary for immunologic activation through redox-sensitive signal transduction pathways, influences antigen presentation and the development/differentiation of immune cells, and modulates the production of cytokines

It appears to reverse cardiac damage by increasing blood vessel growth in injured tissues and activating a cardiac response that may promote healing of the cardiac tissue after an event of myocardial infarction

By hitting these secondary endpoints so strongly against apremilast, Takeda is positioning zasocitinib to fundamentally disrupt the first-line oral and tier-preferred immunology market