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These mechanisms are supported by extensive preclinical and clinical data

Multiple research investigations focusing on the combination of targeted ferroptosis and immune checkpoint blockade (ICB) therapy have indicated that triggering ferroptosis within tumor cells alongside treatment with anti-PD-1 antibodies yields a robust anti-tumor efficacy (Yang F

Overall, Nrf2 is fundamental for the sustenance of the GSH redox state through glutathione reductase transcriptional regulation and for cell protection against oxidative stress (Harvey et al., 2009)

[DOI] [PubMed] [Google Scholar] 103.Zeng J., Fang H., Pan H., Gu H., Zhang K., Song Y

Angiology 55:S19S21 Salinas FM, Vazquez L, Gentilini MV, A OD, Regueira E, Nabaes Jodar MS, Viegas M, Michelini FM, Hermida G, Alche LE and Bueno CA, (2019) Aesculus hippocastanum L