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Unsurprisingly, the various effector and regulatory functions of activated NK-cells are enabled by metabolic programming, which is underpinned by the upregulation of glucose-driven glycolysis, OXPHOS, increased FA synthesis, and glutamine metabolism [370,371,372,373]

PCA of these differentiation stage gene expression profiles, which included primary melanocytes as a reference, showed that each stage segregated progressively along a two-dimensional arc-like trajectory with differentiation

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(c) F luorescence microscopy images of L929 cells cultured on the hydrogels at 20, 10, and 4 mag nifica- tions

Although microbiota supports numerous physiological functions, its balance is susceptible to disruption by various internal and external factors