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Reduced synaptic resilience makes older adults more sensitive to stress, and chronic stress in turn accelerates synaptic dysfunction, a bidirectional feedback loop that may also heighten vulnerability to neurodegenerative diseases such as AD and PD

Interaction of GTPase-activating protein with p21ras, measured using a continuous assay for inorganic phosphate release

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Different patient populations, different trial designs, different enrollment criteria, and different measurement protocols all introduce noise that makes precise numerical comparisons between CagriSema and tirzepatide unreliable

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