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Translational Psychiatry, 3(7), e288

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Because so much of GHK-Cus activity is copper-mediated, it is difficult in some experiments to separate specific tripeptide signaling from generic copper effects a point made concrete by the finding that the MMP-2 effect was reproduced by copper ions alone while the collagen-synthesis effect required the intact peptide

the reduction of PIP 2 activates V3, and in V4, the phospholipid stimulates the channel during response to heat and decreases resistance to muscle stretch

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