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Lancet 2021 Phase 1b (cagri + sema) Enebo et al., n=96, 20 weeks

At least they are provided with reference ranges

Rapid or excessive weight loss is generally not healthy or sustainable

2.13.1.2 E693del (Osaka) mutation The APP E693-Tg (Osaka) mouse model, which carries the Osaka mutation (APP695) under the control of the mouse prion promoter, expressed comparable levels of mutant human APP and endogenous mouse APP