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[2] After the promising results from the 12-week trial, a more extended 24-week trial was conducted with a larger group of 536 subjects

doi:10.3238/arztebl.2019.0692 Prudhon S, Kubis N

Amylin/Pramlintide Combinations Previous animal studies have shown that amylin treatment significantly enhanced hypothalamic anorexigenic leptin signaling, while the combination treatment with amylin and leptin led to marked, synergistic reductions in food intake (up to 45%) and fat-specific weight loss (up to 15%)