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It is reported that some ascorbate-specific transport carriers ensure its diffusion to stroma from the cell cytosol (Foyer and Lelandais, 1996

We previously succeeded in identifying human ACF in situ using magnifying colonoscopy with methylene blue staining, and showed that the number of rectal ACF increased in a stepwise fashion from normal subjects to adenoma patients, and then to cancer patients, suggesting that ACF are precursor lesions to the adenomacarcinoma sequence in humans 13, 14

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