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The Need For Objective Scientific Review and Scrutiny To effectively address this burgeoning public health crisis, policymakers must move beyond outdated substance classifications and implement a regulatory framework capable of matching the agility of the digital gray market

In contrast, pathways including Catecholamine transferase inhibitors and Anticonvulsants were enriched with a higher number of downregulated metabolites

In metabolic regulation, Scrophularia -containing formulations (e.g., Clean-DM1) activate IRS/PI3K/AKT and AMPK signaling pathways, thereby improving insulin resistance and correcting glucose-lipid metabolic dysfunction (138)

10.4103/sni.sni_441_16 Surg

An in vitro metabolomics approach to identify hepatotoxicity biomarkers in human L02 liver cells treated with pekinenal, a natural compound