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GMPs can also affect modulation of digestion via the release of the hormone cholecystokinin (CKK) after protein or fat ingestion (8)

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The inhibition of ISCA2 (a component of the late mitochondrial iron-sulfur cluster assembly complex) reduces the HIF-2 protein level and triggers an iron starvation response, leading to iron/metal overload and contributing to ferroptosis, which is more significant in VHL-defective cells (82)

FGF21 is a pivotal regulator of metabolism, particularly in lipid and glucose pathways, and has been implicated in various mitochondrial disorders

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