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[13] Orally ingested compounds first pass through the gastrointestinal tract and gut microbiome where some xenobiotics can be metabolized before entering the bloodstream, while inhaled, intravenous, or dermal exposures enter circulation more directly

Glutamate analogs such as N -methyl-D-aspartate (NMDA) have been used in murine models to induce an increase in calcium and ROS levels and ultimately the death of RGCs (Seitz and Tamm, 2013)