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He et al.s PBPK model predicted that schisantherin A from Wuzhi capsules exhibited TDI of CYP3A4, while schisantherin B exhibited both RI and TDI of CYP3A4 and CYP3A5

that is, there are not only ROS at the physiological level in follicular fluid but also a variety of antioxidant enzymes and non-enzymatic oxidants (61)