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doi: 10.1007/s10552-008-9283-x

In the completed trial NCT00948961, poly-ICIC and/or Resiquimod combined with NY-ESO-1-targeting DC cell vaccine

Therapeutic monoclonal antibodies, including PD1/PDL1 inhibitors, are eliminated via nonspecific catabolic pathways and do not directly interact with cytochrome P450 enzymes or drug transporters

Its metabolism is catalysed by a number of enzymes that require B-vitamins as cofactors, with homocysteine levels being particularly responsive to folate status