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By month fifteen, the trial's primary endpoint, the average participant had lost 15.2 percent of their starting weight, and the curve had become essentially horizontal [Garvey et al., Nature Medicine, 2022]

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Additionally, choline is crucial for normal brain development, nerve function, and muscle movement

Compounds such as alpha-chloroacetamide-based inhibitors achieve this by covalently binding to a cysteine residue in the SAM-binding pocket of NNMT 202