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There are two main differences: It possesses an Arginine instead of a Glutamic Acid in the third position It also possesses 13 additional Amino Acids at the N-terminus Why these changes

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At present, no multicenter cohort studies have validated biomarkers with both diagnostic and prognostic value, nor has the issue of in vivo molecular imaging sensitivity been overcome, particularly for PET probes targeting transferrin receptors

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Future research should prioritize addressing these challenges to enhance the clinical translation of ferroptosis-targeted therapies

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[DOI] [PMC free article] [PubMed] [Google Scholar] 73.Ruskin D.N., Kawamura M., Masino S.A

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