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Identification of a lipokine, a lipid hormone linking adipose tissue to systemic metabolism

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This randomized, controlled trial compared the effects of L-citrulline (6g) , combined L-citrulline (2g) + glutathione (200mg) , and placebo over 4 weeks

Introduction Glutathione is a tripeptide found in many tissues at relatively high concentrations, namely 110 mM in cells, similarly to glucose, potassium, and cholesterol, with a critical role in several physiological processes, such as redox balance preservation, reduction of oxidative stress through detoxification from xenobiotic and endogenous compounds, and immune system modulation (1)