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[43] As the focus for neurodegenerative diseases begins to shift towards epigenetic pharmacology, it can be expected that the interactions of histone modifications with respect to neurogenesis will become more clear

Several factors combine: absence of active patent (thus little pharmaceutical incentive to finance trials), ambiguous regulatory status in most countries, high cost of a phase I to III clinical trial (several million to tens of million euros), difficulty in defining a precise indication acceptable to a regulatory authority

Research published in 2001 demonstrated that DNMT3a maintains Gfap methylation until E14.5, thereby delaying the differentiation of astrocytes

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19 Phosphorylated Met (pMet) directly recruits adapter proteins such as Gab1, Grb2, and Src, which transmit the signal to two major downstream pathways of Akt and ERK (extracellular-regulated kinase)