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In RLM and HepM models, PDH and 2OGDH activities were the values reported previously ( Supplementary Table S1 )

Antioxidants are molecules that fight free radicals in your body

IL-10 regulates inflammation by suppressing the production of cytokines such as IL-1, IL-1, IL-6, IL-8, IL-12 and TNF- in activated M and IFN- in T-cells

Among these derivatives, the most potent one is a hybrid of ISA/hydroxamic acid, ((3R,4R,6R,8R, 9R)-8-methyl-3,5-dimethylene-2-oxododecahydronaphtho [2,3-b]furan-6-yl (4-((E)-3-(hydroxyamino)-3-oxoprop-1-en-1-yl) benzoyl)- R -alaninate) (Derivative 11, Figure 2K), the IC 50 of which against the cancer cell lines were below 0.3 M (Mo et al., 2024)

Discussion We have created a whole body model of acetaminophen transport and metabolism that includes the details of the biochemical pathways of acetaminophen metabolism in the liver and peripheral tissues