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Interestingly, a recent review of all of the known published cases of mitochondrial disease and ASD demonstrated that only about 25% had a known genetic mutation that could account for their mitochondrial disease ( Treatments that are typically used for patients with mitochondrial disease have been shown to improve functioning in some children with ASD (58, 59) and case reports (6063) have reported improvements in core and associated ASD behaviors with l-carnitine treatment

Intravenous infusion of a fumarate precursor in SS.13 BN rats results in a fumarate excess in the renal medulla comparable with that seen in SS rats and significantly exacerbates salt-induced hypertension in SS.13 BN rats 78

Neurology 85, 16701679

Oxidative stress and oval cell accumulation in mice and humans with alcoholic and nonalcoholic fatty liver disease