The experimental data is listed in table 11.Table 11 The example data of preparation of L-carnitine from L-3-cyano-2-hydroxypropyl trimethylammonium having different optical purity Example 1 Establish the detecting method of the optical purity of epichlorohydrin with gas chromatography Example 2 Detection of the content of the D-isomer of the intermediate (L-3-cyano -2 - hydroxypropyl trimethyl ammonium) Example 3 Preparation of L-carnitine started from S-epichlorohydrin having different optical purity Example 4 Preparation of L-carnitine from L-3-chloro-2-hydroxypropyl trimethylammonium Example 5 Preparation of L-carnitine from L-3-cyano-2-hydroxypropyl trimethylammonium Claims (8) A Preparation Method of high-Purity L-carnitine, characterized in that to prepare L-carnitine with a purity being above 97%, wherein the content of D-carnitine is below 2%, by detecting and controlling the content of chiral material and chiral intermediate during the whole synthetic process which is started from S-epichlorohydrin, wherein the method include the following steps:(1)Detect the content of optical isomers of S-epichlorohydrin with GC and chiral column, and control the content of laevoisomer of S-epichlorohydrin within the range of 0% -12% W/W;(2)Detect the specific rotation of the intermediate L-3-chloro-2-hydroxypropyl trimethylamine during the synthetic process with a polarimeter, and control the value within the range of -26.0 -29.4;(3)Detect the optical purity of L-3-cyan-2-hydroxypropyl trimethylamine of the intermediate mixture and the content of its dextroisomer with a chiral derivatization reagent, and control the content of the dextroisomer within the range of 03.6%W/W;wherein the said chiral derivatization reagent is the optically pure D- or L-compound of formula (II):wherein, the carbon atom marked with an asterisk is the chiral carbon atom
L-citrulline helps the body rid itself of ammonia, a by-product of exercise
Once there, they can be oxidizedused as fuelto generate adenosine triphosphate, or ATP
Il suo utilizzo va preso in considerazione quando si vuole avere maggiore energia durante lallenamento e per la fase di recupero
Crosstalk between acetylation marks and other posttranscriptional modifications of the histones also facilitate the recruitment of transcriptional regulators to the promoter of genes that are subsequently transcribed (reviewed in 7)
