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Heravi, Bioelectrochemistry 77, (2009) 2630

doi: 10.1002/iub.2067 118 VidelaLAVargasRValenzuelaRMuozPCorbariAHernandez-RodasMC

In SLE (systemic lupus erythematosus), ferroptosis occurs in neutrophils as a result of autoantibody and interferon-alpha induced binding of CREM (cAMP response element modulator ) to the GPx4 promoter, leading to inhibition of GPx4 expression and elevation of lipid reactive oxygen species, and SLE also induces osteoclast ferroptosis through downregulation of GPx4, leading to vertebral osteoporosis

Although these side effects occurred in approximately 70 percent of test subjects receiving CJC-1295 DAC, they were transient and lasted no more than a few hours

For herbal drugs containing essential oils, solidliquid forms like suspensions and emulsions are more suitable due to their ability to maintain stability and uniform distribution of active compounds