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Philp, D., Badamchian, M., Scheremeta, B., et al

Eumelanin is responsible for brown to black color and provides the darker skin tones

Through increased labeling of BCKA-derived metabolites and increases in levels of BCAA breakdown, such as glutamate, alanine, and 3-hydroxyisobutyric acid, they discovered that tirzepatide treatment stimulated catabolism of BCAAs/BCKAs in BAT

Patients who take it later in their day consistently report more sleep disruption