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In the hypoxic environment, the phenotype of smooth muscle cells changes from contractile to synthetic, which increases the cells proliferation and migration capabilities

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Moreover, this study found that the catalytic triad of GPx4 is located on a flat surface surrounded by basic amino acid patches, K48/K135/R152/T139, and this particular conformation supports its broad-spectrum substrate specificity, and several studies have demonstrated that the molecular weight of GPx4 proteins is 19-22 kDa

Egger S, David M, Watts C, Dessaix A, Brooks A, Jenkinson E, Grogan P, Weber M, Luo Q, Freeman B (2024) The association between vaping and subsequent initiation of cigarette smoking in young Australians from age 12 to 17 years: a retrospective cohort analysis using cross-sectional recall data from 5114 adolescents