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24 , 13561367.e1358 (2017)

A meta-analysis of the association between two cardiac risk factors

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Monocle2 pseudotime analysis further confirmed that, relative to natural aging, the additional effect of HHcy caused endothelial cells to diverge in different directions and accelerated their transition from pre-aging to senescence, as evidenced by the bifurcation at Branch Point 1 (Figure 2K)