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PMID 28299653

CBS and CSE have been reported to re-localise to mitochondria in response to hypoxia, a common feature of the tumour microenvironment, resulting in targeted H 2 S delivery that can stimulate ATP production and protect mitochondria from oxidative stress

Cells were labeled 50, 35x6, and 4+1 (each group contains 9 samples) to represent the concentration and number of treatments the cells received throughout the metabolic and molecular studies

Immune-cell activation can reorganize nutrient use, NADPH production, mitochondrial metabolism, and thiol-dependent signaling, making glutathione regulation one component of broader immunometabolic control

Requires Mg 2+ as a cofactor Produces ATP The GAPDH and PGK reactions are coupled to allow the energetically unfavorable GAPDH reaction to be pulled forward by the highly favorable PGK reaction