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[Abstract]2025 Sep 3:16:1648467

Dual inhibition of MYC and SLC39A10 by a novel natural product STAT3 inhibitor derived from Chaetomium globosum suppresses tumor growth and metastasis in gastric cancer

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Abbreviations AA: amino acid AD: Alzheimer's disease ATG: autophagy-related gene CDCrel-1: cell division control-related protein CMA: chaperone-mediated autophagy CP: core particle E1: ubiquitin-activating enzyme E2: ubiquitin-conjugating enzyme E3: ubiquitin-ligating enzyme GstS1: glutathione S-transferase S1 GABARAP: g-aminobutyric acid receptor-associated protein HSP 90: heat shock protein 90 KO: knock out LC: locus coeruleus LC3: microtubule-associated protein 1 light chain 3 Pael-R: parkin-associated endothelial-like receptor PD: Parkinson's disease PROTAC: proteolysis targeting chimera Sfp1: split-finger protein 1 SnPc: substantia nigra pars compacta Ub: ubiquitin UCH-L1: carboxyl-terminal hydrolase L1 UPS: ubiquitinproteasome system References Wijeyekoon RS, Moore SF, Farrell K, Breen DP, Barker RA, Williams-Gray CH (2020) Cerebrospinal Fluid Cytokines and Neurodegeneration-Associated Proteins in Parkinson's Disease

Livingston MJ, Wang J, Zhou J, Wu G, Ganley IG, Hill JA, et al