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additionally NAD + can be generated in the mitochondria from NMNAT3 80 , whose activity has been shown to be required in cells 77 , but dispensable in vivo as NAD + can be replenished through other pathways such as import from the cytosol 81

Song Z, Zhong X, Li M, Gao P, Ning Z, Sun Z, Song X (2021b) 1-MNA ameliorates high fat diet-induced heart injury by upregulating Nrf2 expression and Inhibiting NF-B in vivo and in vitro