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doi: 10.1177/1076029620977702 178 MaherP

Biochemistry 35(12):36853694

However, in the absence or inhibition of caspase-8, RIPK1 bypasses Complex IIa formation and instead recruits RIPK3, forming the RIPK1-RIPK3 complex via the RIP homology interaction motif

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The work of Zhang and colleagues demonstrated the accumulation of intracellular ROS and the subsequent activation of the NLRP3 inflammasome in macrophages from mice of the J774.1 line when the P2X7 receptor was activated (Zhang et al., 2021)