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In intrapancreatic CD8+ T cells, lipid accumulation impairs mitochondrial function, but enforced expression of the very-long-chain acyl-CoA dehydrogenase enzyme (ACADVL) can rescue mitochondrial function and protect T cells from lipotoxicity, thereby increasing intratumor T-cell survival and persistence [82]

The published literature calls it well-tolerated

2B, residues 180-326 of GATA4 bound to the 35 S-labeled GATA4

These require emergency care where clinicians can properly titrate fluids, monitor labs, and evaluate sodium levels before anything is infused